Development of colitic mucosa repair therapy by the induction of regeneration-specific stem cell niche formation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293170
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Okamoto Ryuichi 東京医科歯科大学, 再生医療研究センター, 教授 (50451935)
• Co-Investigator(Kenkyū-buntansha): Tsuchiya Kiichiro 東京医科歯科大学, 医学部附属病院消化器内科, 准教授 (40376786) ; Nakamura Tetsuya 東京医科歯科大学, 医歯学総合研究科, 寄附講座教授 (70265809)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 腸管上皮 / 炎症性腸疾患 / Notchシグナル / オルガノイド / ニッチ

Outline of Final Research Achievements

Through the studies of the current project, results were acquired in the following areas: 1) Identification of Dll1+ve or Dll4+ve cells in inflamed and non-inflamed intestinal epithelium, and the functional relevance of those cells, 2) Comprehensive analysis of gene expression in Notch and TNF-α pathway activated cells, which constitute the regenerative epithelium inbt he colitic mucosa and 3) Identification of a distinct intestinal stem cell population that appears at the recovery phase of colitis.

Free Research Field

消化器内科