2015 Fiscal Year Final Research Report
Identification of novel mutations of candidate driver genes in immune pathogenesis of hepatocellular carcinoma
| Project/Area Number |
25293171
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA TARO 金沢大学, 附属病院, 助教 (90377432)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 癌 / 遺伝子 / 核酸 / 動物 / 内科 |
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| Outline of Final Research Achievements |
The current study was designed to identify novel mutations of 119 candidate driver genes in an animal model of immune pathogenesis of hepatocellular carcinoma (HCC). In the tumor tissues, non-synonymous mutations (> 1 %) were detected in the 24 genes and hyper-methylation of CpG islands were observed around the coding region of 7 genes. Gene ontology analysis reveals that these gene changes may be enriched in functions involved in oxidation reduction / mitochondrion / oxidoreductase activity, suggesting the plausible molecular targets for HCC.
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| Free Research Field |
医歯薬学
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