Analysis of microenvironment-mediated treatment resistance of hepatocellular carcinoma in terms of integrated proteomics

2016 Fiscal Year Final Research Report

• Project/Area Number: 25293173
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kumamoto University
• Principal Investigator: Sasaki Yutaka 熊本大学, 大学院生命科学研究部, 教授 (70235282)
• Co-Investigator(Kenkyū-buntansha): 渡邊 丈久 熊本大学, 生命科学研究部, 助教 (20634843) ; 直江 秀昭 熊本大学, 医学部附属病院, 助教 (30599246) ; 荒木 令江 熊本大学, 生命科学研究部, 准教授 (80253722) ; 藤元 治朗 兵庫医科大学, 医学部, 教授 (90199373)
• Co-Investigator(Renkei-kenkyūsha): NAKAO MITSUYOSHI 熊本大学, 発生学研究所, 教授 (00217663)
• Research Collaborator: NAGAOKA KATSUYA 熊本大学, 医学部附属病院, 医員 (00759524)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 肝癌 / 微小環境 / 治療抵抗性 / エピジェネテイクス / プロテオミクス / 翻訳後修飾 / 代謝リプログラミング

Outline of Final Research Achievements

Microenvironment surrounding cancer tissues might contribute much spatiotemporally so that cancer cells could obtain treatment resistance and exhibit biological characteristics. Comprehensive analysis of gene and protein expression in hepatoma cells, associated with analysis of post-translational modification, have described that phosphorylation status of thirty proteins has significantly changed under apoptotic stimulation. These proteins are including chaperon proteins, cytoskeleton-related molecules. In addition, nutritional environment would induce metabolic re-programming in terms of mediating the cross talk between the epigenome and lipid metabolism.

Free Research Field

医歯薬学