Role of lipotoxity in NASH

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293175
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: NAKAJIMA Atsushi 横浜市立大学, 医学(系)研究科(研究院), 教授 (30326037)
• Co-Investigator(Kenkyū-buntansha): SAITO Satoru 横浜市立大学, 医学部, 准教授 (00275041) ; IMAJO Kento 横浜市立大学, 附属病院, 助教 (30600192) ; YONEDA Masato 横浜市立大学, 附属病院, 講師 (10423831)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 脂肪肝 / NASH / NAFLD

Outline of Final Research Achievements

Non Alcoholic Steato-hepatitis (NASH)is a emerging disease which arise from Non Alcoholic Fatty Liver(NAFLD). The number of NAFLD patient is estimated about 20 million in Japan. NASH is the highest number of patients among liver disease. In this study, we investigate the effect of free fatty acid, palmitate on mouse liver. Administration of free fatty acid induced the inflammatory cells infiltration and activate stellate cells and fibrosis formation in the liver. We showed the neutrophil infiltration is caused by the production of the chemokine by the free fatty acids whereas fibrosis directly induced by free fatty acids via TLR4.

Free Research Field

肝臓病学