Identification of cardio protective factors secreted from growing skeletal muscle

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293186
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kumamoto University
• Principal Investigator: Ogawa Hisao 熊本大学, 大学院生命科学研究部, 教授 (50177135)
• Co-Investigator(Kenkyū-buntansha): IZUMIYA YASUHIRO 熊本大学, 大学院生命科学研究部, 助教 (10515414) ; ARAKI SATOSHI 熊本大学, 医学部附属病院, 特任助教 (20706717)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨格筋 / 分泌因子 / 血管新生 / 腎臓病

Outline of Final Research Achievements

It has been shown that skeletal muscle is not only a motor organ but also endocrine organ that secretes various cardio-renal protective factors. We demonstrated that skeletal muscle growth reduces renal damage in a mouse model of obstructive kidney disease. This improvement appears to be mediated by an increase in eNOS signaling in the kidney. Base on proteomic approach, we identified that several factors are secreted form growing skeletal muscle. We found that the Factor-1 served as a muscle-derived angiogenic factor, and Factor 2 and 3 could be a biomarker for the patients with heart failure. We also performed comprehensive analysis of muscle-derived miRNAs. We found that miR-215, miR-9, miR-96 are potential factors which secreted from growing muscle.

Free Research Field

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