Analysis of new candidate genes for essential hypertension: ATP2B1 gene and LPIN1 gene

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293196
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Yokohama City University
• Principal Investigator: UMEMURA Satoshi 横浜市立大学, 医学(系)研究科(研究院), 教授 (00128589)
• Co-Investigator(Kenkyū-buntansha): MIZUKI Nobuhisa 横浜市立大学, 医学研究科, 教授 (90336579) ; HIRAWA Nobuhito 横浜市立大学, 市民総合医療センター, 准教授 (20315766) ; OKA Akira 東海大学, 付置研究所, 講師 (80384866) ; YATSU Keisuke 横浜市立大学, 附属病院, 助教 (10457856) ; KOBAYASHI Yusuke 横浜市立大学, 医学研究科, 客員研究員 (60612629)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ATP2B1遺伝子 / LPIN1遺伝子 / 本態性高血圧

Outline of Final Research Achievements

We have made four tissue specific ATP2B1 KO mice and overexpression ATP2B1 mice for these 3 years.Then, we reported the paper "Impaired nitric oxide production and increased blood pressure in systemic heterozygous ATP2B1 null mice."(J Hypertens. 2014 Jul;32(7):1415-23).
LPIN1 gene is a key regulator of circadian rhythm for blood pressure control. Now, we are making preparation for submitting these data as the first report of key regulator of circadian rhythm for blood pressure control.

Free Research Field

高血圧