2015 Fiscal Year Final Research Report
Identification of target regions for CKD therapy among the molecular structure of (pro)renin receptor.
| Project/Area Number |
25293198
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 慢性腎臓病 / 老化 / 骨格筋 / サルコペニア |
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| Outline of Final Research Achievements |
Rescue experiments using fragments of the (P)RR gene in (P)RR-deficient MEF showed the essential role of the (P)RR extracellular domain in maintenance of cell life. However, once V-ATPase is constructed, processing of the full length (P)RR to the extracellular (P)RR domain is not always necessary for the construction of V-ATPase. In addition, the mice overexpressed soluble (P)RR, that is almost extracellular domain of (P)RR, had no abnormal phenotype. Whereas, the mice overexpressed full-length (P)RR had fast muscle-dominant muscle atrophy mimicked human sarcopenia. The mechanism involved molecules contributing to autophagy, Wnt signals, and Sirt1.
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| Free Research Field |
高血圧、内分泌、腎臓
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