Analysis and manipulation of acellular barrier in human blood-nerve barrier

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293203
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Yamaguchi University
• Principal Investigator: KANDA Takashi 山口大学, 医学(系)研究科(研究院), 教授 (40204797)
• Co-Investigator(Renkei-kenkyūsha): TERASAKI Tetsuya 東北大学, 大学院薬学研究科, 教授 (60155463)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 血液神経関門 / 内皮細胞 / ペリサイト / 基底膜 / ラミニン / 炎症性ニューロパチー

Outline of Final Research Achievements

Major basement membrane proteins composing blood-nerve barrier (BNB) were fibronectin, collagen type IV and laminin alpha 5. Differed from those of blood-brain barrier (BBB), laminin alpha 4 was barely detected. The differences of cellular properties constituting BBB and BNB may be responsible for these variations. Our results suggested that in BNB, without glia limitans which functions as acellular barrier for T cell intrusion in the nervous system parenchyma in BBB, the first basement membrane wrapping endothelial cells and pericytes itself functions as “acellular barrier”.

Free Research Field

神経内科学、神経免疫学