2015 Fiscal Year Final Research Report
Molecular mechanism of pancreatic alpha cell failure in type 2 diabetes
| Project/Area Number |
25293208
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | グルカゴン / Sirt1 |
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| Outline of Final Research Achievements |
Pancreatic alpha cell dysfunction as well as beta cell dysfunction is known to be important for pathophysiology of type 2 diabetes. However, its molecular mechanism has been unclear. Thus, we generated both knockout mice and knockin mice in which Sirt1, an NAD-dependent deacetylase and a cellular energy sensor, lack or overexpress specifically in alpha cells. The metabolic profiles and histological analysis revealed that Sirt1 negatively regulates alpha cell differentiation/proliferation, and positively regulates glucose-dependent glucagon secretion.
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| Free Research Field |
内分泌学
|
