Molecular mechanism of diabetes mellitus based on beta-cell transcription factor network

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293212
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kumamoto University
• Principal Investigator: Yamagata Kazuya 熊本大学, 大学院生命科学研究部, 教授 (70324770)
• Co-Investigator(Kenkyū-buntansha): Yoshizawa Tatsuya 熊本大学, 大学院生命科学研究部, 准教授 (40313530) ; Sato Yoshifumi 熊本大学, 大学院生命科学研究部, 助教 (90622598)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 糖尿病 / インスリン分泌 / 転写因子 / MODY

Outline of Final Research Achievements

Mutations in the genes encoding hepatocyte nuclear factor (HNF) cause impaired insulin secretion and diabetes mellitus. However, the detailed molecular mechanisms are largely unknown. In the present work, we found that Crp is a direct target gene of HNF1 and high sensitive could be a biomarker for HNF1 diabetes. In addition, we found that Tmed6 is a target gene of HNF1. Furthermore, we identified that Anks4b, a direct target of HNF4, regulates insulin secretion by beta-cells.

Free Research Field

代謝学