Study for mechanism of maintaining cutaneous homeostasis by HMGB1-induced mesenchymal stem cell mobilization from bone marrow, and application for treating intractable skin diseases.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293244
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Osaka University
• Principal Investigator: Tamai Katsuto 大阪大学, 医学(系)研究科(研究院), 寄付講座教授 (20236730)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: HMGB1 / 骨髄間葉系幹細胞 / 血小板増殖因子受容体 / 表皮水疱症 / 強皮症 / 再生誘導医療

Outline of Final Research Achievements

In this study, we investigated role of HMGB1 for regulating cutaneous homeostasis, and possibility of HMGB1 application for treating intractable skin diseases. In summary, we clarified following mechanisms; 1) necrotic tissue-derived HMGB1 binds to proteoglycan "syndecan" to be pooled on the cell surface and released when injury occurs, 2) released HMGB1 in the circulation binds to the receptor on the cell membrane of bone marrow mesenchymal stem cells (MSCs) and mobilize them into the circulation, 3) the mobilized MSCs in the circulation target the injured/necrotic tissues by SDF-1/CXCR4 axis generated on the vascular endothelial cell surface, and 4) the mobilized MSCs in the injured tissue then suppress inflammation, reduce scar formation, and induce tissue regeneration.

Free Research Field

皮膚科学、再生医学、遺伝子治療学