2015 Fiscal Year Final Research Report
Research on the method to predict future rupture of intracranial aneurysms in the clinical field
| Project/Area Number |
25293264
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nagoya University |
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Principal Investigator |
Isoda Haruo 名古屋大学, 脳とこころの研究センター, 教授 (40223060)
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| Co-Investigator(Kenkyū-buntansha) |
MIYACHI Shigeru 名古屋大学, 大学院医学系研究科, 准教授 (00293697)
FUKUYAMA Atsushi 名古屋大学, 大学院医学系研究科, 助教 (40452198)
KAWAI Hisashi 名古屋大学, 医学部附属病院, 助教 (50378147)
IZUMI Takashi 名古屋大学, 医学部附属病院, 講師 (90467291)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEHARA Yasuo 浜松医科大学, 医学部附属病院, 准教授 (70188217)
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| Research Collaborator |
ICHIKAWA Kazushige
TOZAWA Ikki
MORI Marika
YONEYAMA Yuya
WATANABE Tomoya
TAKIGUCHI Kazuya
ISHIGURO Kenta
MIZUNO Takashi
TERADA Masaki
KOSUGI Takashi
KOSUGI Takafumi
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 脳動脈瘤 / 血流解析 / 磁気共鳴流体解析 / 計算流体解析 / 磁気共鳴 |
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| Outline of Final Research Achievements |
MR fluid dynamics (MRFD) using 3D cine PC MR dataset for straight acrylic pipes showed that when the ratio of pixel size for the pipe greater or equal to 6 mm was set at 30% or lower, spatially-averaged velocity measurements were highly accurate. A pixel size ratio of 10% or lower allowed accurate maximum velocity measurements. It was difficult to accurately measure maximum velocity of the 3-mm pipe, the size of an intracranial major artery, although the error for spatially-averaged velocity was 20% or less.
Quantitative accuracies in flow vectors and wall shear stress (WSS) for intracranial arteries were not so good in MRFD using computational fluid dynamics (CFD) as a gold standard. However, qualitative accuracies of distribution patterns of streamlines and WSS, and flow patterns were good. Therefore, MRFD can be used in the clinical field. CFD is still necessary for accurate hemodynamic analysis and MR based CFD can predict the initiation of the intracranial aneurysm.
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| Free Research Field |
神経放射線診断学
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