Establishment of adaptive criteria and protocol for accelerator-based BNCT

2017 Fiscal Year Final Research Report

• Project/Area Number: 25293267
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kawasaki Medical School
• Principal Investigator: Hiratsuka Junichi 川崎医科大学, 医学部, 教授 (30192298)
• Co-Investigator(Kenkyū-buntansha): 神谷 伸彦 川崎医科大学, 医学部, 助教 (10614282) ; 櫻井 良憲 京都大学, 原子炉実験所, 准教授 (20273534) ; 粟飯原 輝人 筑波大学, 医学医療系, 准教授 (30268619) ; 田中 了 川崎医科大学, 医学部, 講師 (70412187) ; 河田 裕二郎 川崎医科大学, 医学部, 助教 (00804345) ; 森田 倫正 川崎医科大学, 医学部, 講師 (40341119)
• Co-Investigator(Renkei-kenkyūsha): Kurebayashi Junichi 川崎医科大学, 医学部, 教授 (10248255) ; Makino Eiichi 川崎医科大学, 医学部, 講師 (90314674)
• Project Period (FY): 2013-04-01 – 2018-03-31
• Keywords: BNCT / accelerator / protocol

Outline of Final Research Achievements

This study has been carried out to estimate whether the reactor-based criteria is adaptable for the accelerator-based BNCT. 22 patients, 18 with the head and neck tumors and four with skin malignancies, received BNCT. Acceptable criteria are followings: (1) surgical treatment is rejected and not indicated, (2) the tumor depth is less than 6cm, and without distant metastases, (3) T/N ratio is more than 2.5 using 18F-BPA-PET. Patients with mass or nodular lesion received BPA-PET examination to estimate boron Tumor/Blood ratio. Our results are preliminary, as the patient cohort was very small. Furthermore, we calculated the irradiation doses on data obtained from previous studies. In the other words, we did not directly measure the boron concentration in each tumor. Nevertheless, our clinical responses after BNCT indicate that our calculations were accurate. This outcome strongly supports that it is possible to utilize the reactor-based criteria for the accelerator-based BNCT.

Free Research Field

放射線腫瘍学