2016 Fiscal Year Final Research Report
Development of organ regeneration and transplantation of functional pancreas from iPS cells
| Project/Area Number |
25293277
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中島 祥介 奈良県立医科大学, 医学部, 教授 (00142381)
植田 剛 奈良県立医科大学, 医学部, 助教 (40526810)
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| Research Collaborator |
NAKAMOTO Takahiro
KASUDA Shogo
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 再生医療 / 糖尿病 / iPS細胞 |
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| Outline of Final Research Achievements |
We aimed to induce organ regeneration of "iPanc" from "iGut" by using iPS cells. For clinical application, we tried to induce iPanc by using human iPS cells, but failed to induce human iPanc. We found that mouse iPS-derived heart (iHeart) and iGut have temperature-sensitive ability in motion, which were decreased under 35℃ and failed to move under 30℃. Now we are establishing iPS cells from mouse insulin promotor (MIP)-green fluorescence protein (GFP) mouse. Our results would provide useful information for organ regenerative medicine of iPanc from iGut.
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| Free Research Field |
再生医療
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