The newly invented murine pancreatic cancer model associated with pancreatic developmental master gene Pdx1

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293282
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyoto University
• Principal Investigator: Masui Toshihiko 京都大学, 医学(系)研究科(研究院), 助教 (20452352)
• Co-Investigator(Kenkyū-buntansha): UEMOTO SHINJI 京都大学, 医学研究科, 教授 (40252449)
• Co-Investigator(Renkei-kenkyūsha): KAWAGUCHI YOSHIYA 京都大学, 医学研究科, 教授 (60359792)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 膵発癌 / 非自律的増殖

Outline of Final Research Achievements

In this project, we tried to elucidate the function of pancreatic developmental master gene Pdx1 in the pancreatic carcinogenesis, since there are many common characteristics in the behavior of the cancer cells and of the developmental cells. We knockout pdx1 expression in the genetic manipulated murine pancreatic cancer model and found an exaggeration of the tumor development contrary to our preliminary results. Surprisingly, this phenomenon was observed not only in the knockout cells with K-ras or p53 mutations but also in the genetically normal cells, which indicates the non-autonomous development of cancer cells from normal tissue. We are now seeking the factors inducing this non-autonomous development.

Free Research Field

膵臓外科学