Development of a catheter-based itravascular rotary blood pump for assisting selective blood circulation in heart failure

2016 Fiscal Year Final Research Report

• Project/Area Number: 25293300
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Sumikura Hirohito 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 (20433998)
• Co-Investigator(Kenkyū-buntansha): 妙中 義之 国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 所長 (00142183) ; 巽 英介 国立研究開発法人国立循環器病研究センター, 研究所, 部長 (00216996) ; 大沼 健太郎 桐蔭横浜大学, 医用工学部, 講師 (50527992)
• Co-Investigator(Renkei-kenkyūsha): TAKEWA Yoshiaki 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (20332405) ; TSUKIYA Tomonori 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (00311449) ; MIZUNO Toshihide 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (40426515) ; HOMMA Akihiko 東京電機大学, 理工学部, 教授 (20287428)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 補助循環装置 / 血液ポンプ / カテーテル / モータ / 心不全治療

Outline of Final Research Achievements

In this study, a catheter-based intravascular rotary blood pump for assisting renal blood circulation was developed. The prototype blood pump was manufactured based on computational fluid dynamics analysis results and its pump performance was evaluated in in vitro experiment. In addition, the hydraulic performance of the prototype blood pump was evaluated using a mock circulation circuit which included renal arterial branch under pulsatile systemic hemodynamic condition. The results of in vitro experiments, a flow rate of 1 L/min for a 50 mmHg pressure head was achieved at rotational speed of approximately 25,000 rpm in the prototype blood pump. Additionally, the prototype blood pump was able to increase renal arterial flow and pressure of both renal arteries selectively. The developed catheter-based intravascular rotary blood pump displayed sufficient performance for assisting both renal arteries.

Free Research Field

医用生体工学