New surgical strategy for lung cancer based on circulating tumor cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293301
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Osaka University
• Principal Investigator: Sawabata Noriyoshi 大阪大学, 医学(系)研究科(研究院), 教授 (50403184)
• Co-Investigator(Kenkyū-buntansha): INOUE Masayoshi 京都府立医科大学, 医学系研究科, 教授 (10379232) ; OKUMURA Meinoshin 大阪大学, 医学系研究科, 教授 (40252647) ; FUNAKI SOuichirou 大阪大学, 医学系研究科, 講師 (50465241) ; SHINTANI Yasushi 大阪大学, 医学系研究科, 准教授 (90572983)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 肺癌 / 循環癌細胞 / 手術 / 再発 / 多施設共同研究

Outline of Final Research Achievements

Clinical implication of isolated tumor cells (ITC) in surgical cases of lung cancer were demonstrated using samples of extracted tumor cells at the surgical margin, circulating tumor cells in the blood drained pulmonary vein of the resected lung lobe and peripheral arterial blood. In detail, it is revealed that the morphology of ITC was associated with severity of stromal reaction which is a surrogate marker of epithelial-mesenchymal transition and the degree of tumor malignancy. In addition, cancer cell dislodgement by surgical manipulation is demonstrate and this phenomenon is confirmed in a multicenter prospective study.

Free Research Field

呼吸器外科