Systematic Approach for the Enhancement of Cognitive Function by the Activation of Angiotensin Type 2 receptor Associated Protein

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293310
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Ehime University
• Principal Investigator: Horiuchi Masatsugu 愛媛大学, 医学(系)研究科(研究院), 教授 (40150338)
• Co-Investigator(Kenkyū-buntansha): Mogi Masaki 愛媛大学, 大学院医学系研究科, 准教授 (20363236) ; Iwanami Jun 愛媛大学, 大学院医学系研究科, 助教 (90624792)
• Co-Investigator(Renkei-kenkyūsha): Ohshima Kousei 愛媛大学, 医学部附属病院, 医員 (10598626)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アンジオテンシン / 受容体 / 認知機能

Outline of Final Research Achievements

We observed that cognitive impairment after bilateral common carotid artery stenosis (BCAS), as a model of vascular dementia, was more marked in angiotensin type 2 (AT2) receptor knockout (KO) mice compared with that in wild-type (WT) mice, and that the overexpression of AT2 receptor interacting protein (ATIP) could protect cognitive impairment after BCAS. We also reported that angiotensin converting enzyme (ACE2) KO mice exhibited significant impairment of spatial cognitive function. These results suggest that protective arm of renin-angiotensin system (RAS) could attenuate cognitive decline after ischemic brain damage. Moreover, we proposed a new mechanism by which ATIP could plays an important roles in neurons and vascular smooth muscle cells as transcription factor as a member of protective arm of RAS.

Free Research Field

分子心血管・薬理学、心血管リモデリング、脳血管疾患におけるレニン・アンジオテンシン系