Development of new treatments using pro-angiogenic and tissue-specific microRNAs for the injury of musculoskeletal and nerve tissue

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293324
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Hiroshima University
• Principal Investigator: KAMEI NAOSUKE 広島大学, 病院(医), 講師 (70444685)
• Co-Investigator(Kenkyū-buntansha): OCHI MITSUO 広島大学, その他部局等, 学長 (70177244) ; MIYAKI SHIGERU 広島大学, 病院, 講師 (10392490) ; NAKASA TOMOYUKI 広島大学, 病院, 病院助教 (60467769) ; ISHIKAWA MASAKAZU 広島大学, 医歯薬保健学研究院, 助教 (60372158)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 脊椎脊髄病学 / 筋・神経病学 / 運動器外傷学 / 関節病学 / 再生医学

Outline of Final Research Achievements

The administration of miR-210 to the mouse spinal cord injury model promoted angiogenesis and astrogliosis, and improved functional recovery after spinal cord injury compared with the non-injected controls. Additionally, the administration of miR-145 to the same model improved functional recovery and inhibited the expression of semaphorin 3A.
An intra-articular injection of ds miR-210 was effective in the healing of the damaged white zone meniscus through promotion of the collagen type 2 production from meniscus cells and through upregulated of VEGF and FGF2 from synovial cells. The administration of miR-210 to the rat calcaneal tendon injury model promoted the repair of a calcaneal tendon at early phase follow injury.

Free Research Field

脊椎脊髄病学