2015 Fiscal Year Final Research Report
Development of new treatments using pro-angiogenic and tissue-specific microRNAs for the injury of musculoskeletal and nerve tissue
Project/Area Number |
25293324
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Hiroshima University |
Principal Investigator |
KAMEI NAOSUKE 広島大学, 病院(医), 講師 (70444685)
|
Co-Investigator(Kenkyū-buntansha) |
OCHI MITSUO 広島大学, その他部局等, 学長 (70177244)
MIYAKI SHIGERU 広島大学, 病院, 講師 (10392490)
NAKASA TOMOYUKI 広島大学, 病院, 病院助教 (60467769)
ISHIKAWA MASAKAZU 広島大学, 医歯薬保健学研究院, 助教 (60372158)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 脊椎脊髄病学 / 筋・神経病学 / 運動器外傷学 / 関節病学 / 再生医学 |
Outline of Final Research Achievements |
The administration of miR-210 to the mouse spinal cord injury model promoted angiogenesis and astrogliosis, and improved functional recovery after spinal cord injury compared with the non-injected controls. Additionally, the administration of miR-145 to the same model improved functional recovery and inhibited the expression of semaphorin 3A. An intra-articular injection of ds miR-210 was effective in the healing of the damaged white zone meniscus through promotion of the collagen type 2 production from meniscus cells and through upregulated of VEGF and FGF2 from synovial cells. The administration of miR-210 to the rat calcaneal tendon injury model promoted the repair of a calcaneal tendon at early phase follow injury.
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Free Research Field |
脊椎脊髄病学
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