2015 Fiscal Year Final Research Report
Elucidation of novel cell communications in skeletal muscle tissue
| Project/Area Number |
25293326
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Jimi Eijiro 九州歯科大学, 歯学部, 教授 (40276598)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 骨格筋 / 異所性骨化 / 炎症 / 細胞内シグナル |
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| Outline of Final Research Achievements |
In some pathological conditions, skeletal muscle tissues show heterotopic ossification. Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by progressive heterotopic ossification in skeletal muscle due to a genetic mutation of ALK2, a BMP type I receptor. We found that Smad9 has unique functions among substrates of BMP receptors, such as Smad1 and Smad5. A component of NFkB signaling, p65, suppressed the Smad-dependent BMP activity by direct interaction with Smad4. Mutant ALK2 identified in patients with FOP were synergistically activated by BMP type II receptors in a kinase activity-dependent manner. These results suggest that the heterotopic ossification caused by muscle trauma in FOP might be induced by ligands activated indirectly by inflammatory reactions in the skeletal muscle.
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| Free Research Field |
病態生理学
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