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2015 Fiscal Year Final Research Report

Elucidating mechanisms of non-cell-autonomous osteoblast activation

Research Project

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Project/Area Number 25293327
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionKeio University

Principal Investigator

MATSUO Koichi  慶應義塾大学, 医学部, 教授 (40229422)

Co-Investigator(Renkei-kenkyūsha) TAKADA Ichiro  慶應義塾大学, 医学部, 特任講師 (50361655)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywords骨芽細胞 / 骨形成 / 毛細血管
Outline of Final Research Achievements

Transgenic mice overexpressing the transcription factor Fra-1 (Fra-1 mice) exhibit activation of bone-forming osteoblasts leading to enhanced bone formation. We therefore analyzed mechanisms by which bone formation is enhanced in Fra-1 mice. We found that "osteogenic capillaries" form bone matrix around the capillaries in the auditory ossicle malleus during endochondral ossification. We propose that Fra-1 overexpression enhances systemic bone formation by employing osteogenic capillaries in a cell-non-autonomous manner.

Free Research Field

骨代謝学

URL: 

Published: 2017-05-10  

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