Thermoregulation by stress hormones during perioperative period

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293328
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Kagoshima University
• Principal Investigator: Kanmura Yuichi 鹿児島大学, 医歯学域医学系, 教授 (30211189)
• Co-Investigator(Kenkyū-buntansha): KUWAKI Tomoyuki 鹿児島大学, 医歯学域医学系, 教授 (80205260) ; HASEGAWA Maiko 鹿児島大学, 医歯学域医学系, 准教授 (20516637)
• Research Collaborator: KASHIWADANI Hideki ; KUSUMOTO Ikue ; KUROKI Chiharu ; YAMAGUCHI Keiji ; TASHIRO Shogo ; YAMAGUCHI Ran ; KAJIYA Katsuko
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 防御反応 / オレキシン / 周術期管理 / 遺伝子改変マウス / 体温調節 / ストレス / TRPA1 / 呼吸調節

Outline of Final Research Achievements

The aim of this study was to reveal possible modification by stress hormones of thermoregulation during perioperative period. From clinical and experimental studies, we found that orexin is critically important for thermoregulation during perioperative period. We conclude that we should pay special attention to keep body temperature of narcolepsy patients who lack orexin within a normal range to avoid aversive side effects from anesthesia.

Free Research Field

麻酔・蘇生学