The research to explore novel effect of anesthetic agents with comprehensive behavioral test battery

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293330
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Yokohama City University
• Principal Investigator: GOTO Takahisa 横浜市立大学, 医学(系)研究科(研究院), 教授 (00256075)
• Co-Investigator(Kenkyū-buntansha): MIYAZAKI Tomoyuki 横浜市立大学, 医学部, 助教 (30580724) ; UCHIMOTO Kazuhiro 横浜市立大学, 医学研究科, 客員講師 (50710951) ; TAKASE Kenkichi 自治医科大学, 医学部, 教授 (80381474)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 行動テストバッテリー / 麻酔薬

Outline of Final Research Achievements

Besides the sedative effect of anesthetic agents, they exert adverse effect on post-anesthetic cognition. However other effects but sedation of anesthetic agents can be converted into positive effects in the another paradigm. We established comprehensive behavioral test battery to examine the effect of anesthetic agents on higher brain function. 1)exposure to isoflurane disrupts attention function. 2)exposure to desflurane shows no effect on higher brain function. 3)exposure to sevoflurane induces anti-depressive phenotype.

Free Research Field

麻酔科学