2015 Fiscal Year Final Research Report
Exploit of novel preeclampsia model mice by a simple intervention, and elucidation of mechanism of onset of it
| Project/Area Number |
25293342
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka University |
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Principal Investigator |
KUMASAWA KEIICHI 大阪大学, 医学(系)研究科(研究院), 助教 (90444546)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Tadashi 大阪大学, 大学院医学系研究科, 教授 (90240845)
NAKAMURA Hitomi 大阪大学, 大学院医学系研究科, 助教 (80467571)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 妊娠高血圧症候群 / 胎盤特異的遺伝子導入 |
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| Outline of Final Research Achievements |
We performed novel intervention Z to pregnant mice at embryonic 10 day. The mice revealed preeclamptic phenotype. The intervention Z did not increase abortion rate. However the placenta was accompanied with hypoxia, which is usual in preeclamsia.
Four days after the intervention, blood pressure began to elevate. And after delivery the blood pressure recovered to the non-pregnant level. This phenotype mimicked the human preeclampsia. Additionally using the angiogenic factor W, we succeeded in the amelioration of hypertensive phenotype induced induced by the intervention Z.
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| Free Research Field |
医歯薬学
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