International study to elucidate the pathogenesis and genetic predisposition of SJS / TEN with severe ocular complications

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293355
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: SOTOZONO CHIE 京都府立医科大学, 医学(系)研究科(研究院), 教授 (30216585)
• Co-Investigator(Kenkyū-buntansha): KINOSHITA Shigeru 京都府立医科大学, 医学研究科, 教授 (30116024) ; UETA Mayumi 京都府立医科大学, 医学研究科, 准教授 (60398386)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: Stevens-Johnsons症候群 / 遺伝子多型 / HLA

Outline of Final Research Achievements

We performed a genome-wide association study of SJS / TEN with severe ocular complications using Axiom Chip for East Asian ethnics and found the significant association with IKZF1 gene SNPs, and that the significant association with IKZF1 gene SNPs was also observed in Korean people and Indian people. We also found the significant association with HLA-A*02:06 in Japanese and Korean, and the significant association with HLA-B*44:03 in Indian and Brazilian Caucasian. Furthermore, we found the significant association with PTGER3 SNPs and the interaction between PTGER3 SNP and HLA-A*02:06 in Japanese.

Free Research Field

眼科学