Elucidation of the mechanism to control tear secretion by anti-aging approach

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293356
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: Tsubota Kazuo 慶應義塾大学, 医学部, 教授 (40163878)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ドライアイ / 涙腺 / 涙液

Outline of Final Research Achievements

A purpose of this study is to contribute to condition of a patient elucidation of dry eye syndrome caused by aging and a lifestyle-related disease. By using life style-related disease developing mice, we examined the elucidation of age related molecules and effect of the functional foods factor which had the antioxidant action in the lacrimal glands. As a result, aging-related molecules significantly showed a low value in a lifestyle-related disease developing mice. In addition, it became clear that increase in tear secretion volume and secretion-related molecules by giving a functional foods factor.　We demonstrated that the aging and dry eye syndrome are a close relationship to a lifestyle-related disease. Our findings should be crucial in condition of a patient elucidation and therapeutic treatment of dry eye syndrome.

Free Research Field

ドライアイ