The effects of liposomal LF on growth, invasion and bone destruction of oral squamous cell carcinoma (OSCC)

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293373
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Takata Takashi 広島大学, 医歯薬保健学研究院(歯), 教授 (10154783)
• Co-Investigator(Kenkyū-buntansha): Miyauchi Mutsumi 広島大学, 医歯薬保健学研究院, 准教授 (50169265) ; Inubushi Toshihiro 広島大学, 医歯薬保健学研究院, 助教 (30550941) ; Masanobu Shindo 北海道大学, 歯学研究科, 教授 (20162802) ; Furusho Hisako 広島大学, 医歯薬保健学研究院, 助教 (00634461) ; Maishi Nako 北海道大学, 遺伝子制御研究所, 助教 (00632423)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ラクトフェリン / 口腔癌 / 増殖抑制 / 腫瘍性血管 / 血管形成 / アポトーシス / 骨浸潤 / 破骨細胞

Outline of Final Research Achievements

The aim of the study was to clarify the effects of bLF on growth, invasion and bone destruction of oral squamous cell carcinoma (OSCC). Results show 1. Oral administration of liposomal LF inhibits proliferation of OSCC and suppresses bone invasion of OSCC. 2. LF suppresses proliferation of OSCC cells and induces apoptosis of OSCC cells. 3. LF inhibits mobility and invasion of OSCC cells. 4. LF inhibits osteoclastogenesis related molecules in OSCC cells. and 5. LF inhibits tumor angiogenesis by inhibiting proliferation and differentiation of tumor related endothelial cells. Taking together, LF may be a novel therapeutic drug beneficial for the inhibition of OSCC cell proliferation, migration and bone invasion.

Free Research Field

口腔病理学