Development of bioactive resin containing the capacity to induce periodontal tissue formation

2016 Fiscal Year Final Research Report

• Project/Area Number: 25293388
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Kyushu University
• Principal Investigator: MAEDA HIDEFUMI 九州大学, 歯学研究科(研究院), 教授 (10284514)
• Co-Investigator(Kenkyū-buntansha): 和田 尚久 九州大学, 大学病院, 教授 (60380466) ; 友清 淳 九州大学, 大学病院, 講師 (20507777) ; 赤峰 昭文 九州大学, 歯学研究科(研究院), 教授 (00117053) ; 門野内 聡 九州大学, 歯学研究科(研究院), 助教 (30609558)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: バイオアクティブレジン / 歯根膜組織 / 4-META/ MMA-TBBレジン / ナノハイドロキシアパタイト

Outline of Final Research Achievements

In this study, we aimed at developing the bioactive resin that contains the capacity to adhere the dentin and induce the formation of periodontal tissue around it in vivo. When 4-META/ MMA-TBB resin was mixed with calcium chloride or nano-sized hydroxyapatite (nHAP/SB) and then cultured with human periodontal ligament cells, it promoted bone-related gene expression. In addition, tensile test about the adhesion of this resin to bovine dentin showed the same strength level as that of the 4-META/ MMA-TBB resin mixed with nothing. When nHAP/SB was furthermore wrapped with the periodontal ligament cell sheet was embedded into rat extraction socket after 4 weeks of extraction, we found the hard tissue formation around it and moreover fibrous tissue formation around this hard tissue while Shapey’s fiber formation was not observed. These results suggested that nHAP/SB could be a candidate of the bioactive resin.

Free Research Field

歯科保存学