Establishment of iPS cell-based bone tissue engineering using small molecule compounds

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293395
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Tohoku University
• Principal Investigator: Egusa Hiroshi 東北大学, 歯学研究科(研究院), 教授 (30379078)
• Co-Investigator(Kenkyū-buntansha): YATANI Hirofumi 大阪大学, 大学院歯学研究科, 教授 (80174530)
• Co-Investigator(Renkei-kenkyūsha): MATSUMOTO Takuya 岡山大学, 大学院医歯薬学総合研究科, 教授 (40324793) ; SAEKI Makio 新潟大学, 大学院医歯学総合研究科, 教授 (30273692)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 再生歯学 / 骨再生 / iPS細胞 / 小分子化合物

Outline of Final Research Achievements

Bone regeneration and augmentation in dental treatments cannot be easily accomplished because conventional bone grafting materials are not osteoinductive. Induced pluripotent stem cells (iPS cells) are expected to be useful for alveolar bone augmentation/regeneration; however, their clinical application will require complete differentiation toward an osteogenic cell fate to avoid tumor formation. In this research project, we found several small molecule compounds, which enhance osteogenic differentiation of iPS cells, and that application of statins to iPS cell constructs enables efficient bone augmentation and suppresses tumor formation in an animal model. These findings represent an important step toward the therapeutic application of iPS cells to bone tissue engineering in dentistry.

Free Research Field

歯科補綴学