Epigenetic regulation underlying bone and cartilage regenaration

2016 Fiscal Year Final Research Report

• Project/Area Number: 25293401
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Osaka University
• Principal Investigator: Hata Kenji 大阪大学, 歯学研究科(研究院), 准教授 (80444496)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 軟骨細胞 / エピジェネティクス

Outline of Final Research Achievements

Accumulating evidences demonstrated that epigenetic regulation play important roles in tissue regeneration including bone and cartilage regeneration. However, epigenetic regulatory mechanism underlying bone and cartilage development remains to be elusive. In this study, we established several cloning strategy to identify novel epigenetic factors controlling bone and cartilage development. We have identified Foxc1/Foxc2 and found that Foxc1/Foxc2 regulates Ihh-Gli2 signaling during endochondral bone development. We believe that these findings would contribute to the development of novel regenerative medicine for bone and cartilage.

Free Research Field

口腔生化学