A Landscape Genetic Study of Dengue Vector Mosquitoes in The Philippines: Dispersal Pattern and Infection Route

2015 Fiscal Year Final Research Report

• Project/Area Number: 25303020
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Civil and environmental engineering
• Research Institution: Ehime University
• Principal Investigator: Watanabe Kozo 愛媛大学, 理工学研究科, 准教授 (80634435)
• Co-Investigator(Kenkyū-buntansha): OMURA Tatsuo 東北大学, 未来科学技術共同研究センター, 教授 (30111248) ; WATANABE Toru 山形大学, 農学部, 教授 (10302192)
• Co-Investigator(Renkei-kenkyūsha): OSHITANI Hitoshi 東北大学, 医学研究科, 教授 (80419994) ; SAITO Mariko 東北大学, 医学研究科, 助教 (80404234)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: デング熱 / ベクター感染症 / 集団遺伝 / 蚊 / フィリピン

Outline of Final Research Achievements

We assessed the spatial population genetic structure of dengue vector mosquito Aedes aegypti in Metro Manila and Tarlac city in the Philippines. The analysis inferred a strong dispersal activity of Ae aegypti based on the observed low genetic differentiation among populations. However, fine scale population structuring was also detected based on the generated dendrogram and the identification of 3 genetic populations. Based on auto-correlation among local populations, their flight distance was estimated < 5km. In addition, we also developed a GIS-based prediction model of local dengue risk focusing on flood intensity and land use classification in all 604 administrative district in Metro Manila. Using these data, we constructed a regression tree model that describes the spatial variation of dengue infection rate of the administrative section. The model was estimated with high accuracy, and flooding has also been shown that a high contribution as a risk factor.

Free Research Field

生態疫学