Genetic diversity and evolutionary history of HCV genotype 6 variants in Southeast Asia

2015 Fiscal Year Final Research Report

• Project/Area Number: 25305006
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Experimental pathology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: ABE KENJI 国立感染症研究所, その他部局等, 研究員 (60130415)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: B型肝炎 / C型肝炎 / 肝癌 / ウイルス変異株 / ウイルスゲノタイプ / エマージング感染症 / ベトナム / 東南アジア

Outline of Final Research Achievements

In Vietnam and Cambodia, we confirmed 3 different genotypes consists of genotypes 1, 2 and 6 were prevalent. In both countries, genotype 6 variants were most predominant (more than half), followed by genotype 1 and genotype 2. We identified multiple HCV lineages (6a/6e/6h/6k/6l/6o/6p) in Vietnam may represent the indigenous strains; 1a was probably introduced from the US; 1b and 2a possibly originated in East Asia; while 2i/2j/2m were likely brought by French explorers. Furthermore, we inferred the evolutionary history for four major subtypes (1a/1b/6a/6e). The obtained Bayesian Skyline Plots (BSPs) consistently showed the rapid HCV population growth from 1955 to 1963 until 1984 or after, corresponding to the era of theVietnam War. In addition, virological and pathological characteristics of hepatocellular carcinoma (HCC) in Vietnam and occurrence of occult B/C infection among non-B/non-C HCC patients in various countries were reported.

Free Research Field

感染病理学、国際感染症学