2015 Fiscal Year Final Research Report
Joint Cooperative Research for Endemic Diseases Control in Ghana
Project/Area Number |
25305008
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 海外学術 |
Research Field |
Parasitology (including sanitary zoology)
|
Research Institution | Okayama University |
Principal Investigator |
KIM Hye-Sook 岡山大学, 医歯(薬)学総合研究科, 准教授 (70314664)
|
Co-Investigator(Kenkyū-buntansha) |
DOI Hiroyuki 岡山大学, 大学院医歯薬学総合研究科, 教授 (20452568)
KATO Nobuyuki 岡山大学, 大学院医歯薬学総合研究科, 教授 (40150883)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | マラリア / リーシュマニア症 / HCV / 遺伝子解析 / 創薬シーズ |
Outline of Final Research Achievements |
The epidemiological study of Leishmaniasis was L. major only using lesion of several different parts of patients and major vector was S. Africana in the Volta region. In the genetic analysis of drug-resistant malaria, most of the patient samples collected after 2010 showed a drug-sensitive gene type and one of reason of the result was caused by Ghana government malaria treatment-polish was changed to Artemisinin-based combination therapy than other classical malaria drugs.To effective analysis of HCV patient in Ghana, the universal primer-set was determined in the 5'-untranslated region of HCV genome. We found a new drug discovery seeds showing the ability to inhibit both of malaria and leishmaniasis using in Milletia Thonningii of Ghanaian natural products.
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Free Research Field |
医薬品開発、感染症制御
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