2016 Fiscal Year Final Research Report
Molecular epidemiology and population dynamics of rotaviruses in Asia based on novel comprehensive whole genomic analysis method
| Project/Area Number |
25305022
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Hygiene and public health
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鷲見 紋子 札幌医科大学, 医学部, 准教授 (10363699)
漆原 範子 札幌医科大学, 医学部, 講師 (80396308)
ゴッシュ ソウビック 札幌医科大学, 医学部, 助教 (30597175)
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| Research Collaborator |
AIDA Satoru
WANG Yuanhong
PAUL Shyamal
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | ロタウイルス / ゲノム / 分子疫学 / 遺伝子分節 / 遺伝子交雑 / アジア / 下痢症 |
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| Outline of Final Research Achievements |
Epidemic dynamics for long periods of human rotaviruses in Asia was analyzed molecular epidemiologically based on whole genome (11 gene segments). In Wuhan, China, G3P[8] was the most prevalent genotype of rotaviruses over past 10 years, which was thereafter replaced by G9P[8]. Change of lineages was detected for most of their gene segments with the passage of time. In Bangladesh, two lineages of the most prevalent G2P[4] genotype in 2010 were replaced by a novel lineage after 3 years. These findings indicated that replacement of gene segments via reassortment and mutation occurred over time among rotaviruses with prevalent genotypes. It was suggested that genetic changes have been occurring constantly even among the same genotype of rotaviruses.
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| Free Research Field |
衛生学、微生物学
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