Common environmental and genetic factors of ALS/PDC between Kii and Guam

2017 Fiscal Year Final Research Report

• Project/Area Number: 25305030
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Neurology
• Research Institution: Mie University
• Principal Investigator: KOKUBO YASUMASA 三重大学, 地域イノベーション学研究科, 招へい教授 (60263000)
• Co-Investigator(Kenkyū-buntansha): 葛原 茂樹 鈴鹿医療科学大学, 看護学部, 教授 (70111383)
• Co-Investigator(Renkei-kenkyūsha): TSUJI Syouji 東京大学, 医学系研究科, 特任教授 (70150612)
• Project Period (FY): 2013-04-01 – 2018-03-31
• Keywords: 筋萎縮性側索硬化症 / パーキンソン認知症複合 / 紀伊半島 / グアム島 / 神経変性疾患 / 難病 / 認知症 / パーキンソン症候群

Outline of Final Research Achievements

①After 1960’, ALS/PDC, especially ALS, has been decreasing in the Kii peninsula subsequently to on Guam island.②No or only subtle accumulation of BMAA (β-Methylamino-L-alanine) in the brains of Kii patients.
③GWAS revealed candidate SNPs of 5 chromosomes in the patients with Kii ALS/PDC. The diagnostic criteria and severity index were published under supervision by the Japanese Society of Neurology.④New articles regarding neurotoxic BMAA, cerebellar neuropathology, OPTN neuropathology and nitration stress have been accepted by several international journals.

Free Research Field

医学