2015 Fiscal Year Final Research Report
A new method for accurate estimation of AUC for repeated intravenous infusions
| Project/Area Number |
25330042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Statistical science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Fukumoto Mariko 北里大学, 薬学部, 准教授 (40137914)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 血中濃度曲線下面積 / 薬物動態解析 / ブスルファン / ブートストラップ法 / テーラメード治療 |
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| Outline of Final Research Achievements |
To reduce the number of blood samples necessary to estimate the optimal dose of drugs, various kinds of limited sampling strategies (LSSs) have been proposed. However, the conditions under which LSSs succeed or fail in intravenous infusion were not clarified. We investigated the accuracy and precision of existing LSSs numerically, and clalified when a LSS succeeds or fails. Consequently, we developed a new LSS for the estimation and proved that it provides an accurate and precise estimation of the optimal dose.
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| Free Research Field |
医療情報学
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