Basic research on alternative HIV therapy by inducing self-destruction of HIV-1 quasi-population

2016 Fiscal Year Final Research Report

• Project/Area Number: 25330336
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Life / Health / Medical informatics
• Research Institution: Toyohashi University of Technology
• Principal Investigator: Harada Koji 豊橋技術科学大学, 工学(系)研究科(研究院), 助教 (40390504)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: HIV-1 / エイズ / 数理モデル / 代替療法 / 致死的突然変異生成

Outline of Final Research Achievements

In this research project, a basic study by computer simulation and mathematical analysis was conducted to establish a novel HIV-1 therapy based on the concept of the lethal mutagenesis replacing multiple drug combination therapy. In the alternative therapy, viruses are eliminated from virus-infected individuals by depriving the infectious ability from the virus by inducing mutations in viral genes by a chemical mutagen. As a result, it clarified that at least the following two conditions must be satisfied in order to eliminate HIV from HIV-1 infected individual by the alternative therapy. Specifically, 1) the efficacy of a mutagen exceeds a certain threshold value. 2) the virus production rate of wild-type HIV is below a certain threshold. In particular, 1) is considered to be the cause of failure of Phase II clinical trial for the mutagen KP-1461.

Free Research Field

数理生物学