2016 Fiscal Year Final Research Report
Study on mechanisms of contrast gain control in retinal neural circuits
| Project/Area Number |
25330353
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | Chukyo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 網膜オフ型双極細胞 / 順応 / 数理モデル / 光応答シミュレーション / グルタミン酸レセプタ / 錐体視細胞 |
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| Outline of Final Research Achievements |
The contrast gain control which is expressed by a word as light and contrast adaptation is one of the important visual information processing to smoothly transmit information of fluctuation of the brightness on a retina to central nerves systems. In this research, mathematical models from cones to bipolar cells which are the first neural circuit for the contrast gain control were constructed by ionic mechanisms based on physiological evidences. The results that analyzed by using the models suggest that neural mechanisms existing in photo-transduction of the cone photoreceptors and glutamate receptors of the off type bipolar cells will participate in contrast gain control.
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| Free Research Field |
神経情報処理
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