2015 Fiscal Year Final Research Report
Involvement of DNA damage-independent and ATM-dependent stress response in tumor suppressive mechanism
| Project/Area Number |
25340028
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Risk sciences of radiation and chemicals
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | ATM / 酸化ストレス |
|---|
| Outline of Final Research Achievements |
ATM is involved in the regulation of energy metabolism, which is important for malignancy of glioma, via AMPK phosphorylation in addition to its DNA damage response. This energy metabolism pathway, especially mitochondrial energy production, may be an effective therapeutic target for glioma patients.
|
| Free Research Field |
細胞生物学
|
