Molecular mechanism of radiation induced-leukemia using the animal model

2016 Fiscal Year Final Research Report

• Project/Area Number: 25340032
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Hiroshima University
• Principal Investigator: Sasatani Megumi (豊島めぐみ) 広島大学, 原爆放射線医科学研究所, 助教 (80423052)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: ゲノム障害 / ゲノム修復 / 放射線 / 発がん / 白血病 / 突然変異

Outline of Final Research Achievements

Ionizing radiation increases the risks of leukemia and certain types of solid tumors. The relative risk of radiation-induced leukemia is much higher than those of solid tumors. Recently, Dr. Nakamura has hypothesized about the mechanism of radiation induced leukemia where the radiation-related acute lymphoid leukemia (ALL) risk for a population is almost entirely attributable to a small number of predisposed individuals in whom relatively large numbers of translocation-carrying pre-ALL cells have accumulated. To prove this hypothesis, we focused on BCR/ABL fusion gene which is a one of common chromosomal translocations known as Philadelphia chromosome and explored radiation induced tumorigenesis study by using BCR/ABL transgenic mice (BCR/ABLTg/- mice). Our data showed that BCR/ABLTg/- mice are susceptible to radiation-induced thymic lymphoma development.

Free Research Field

放射線生物学