Advanced research on the biological effects of genotoxic stress using different irradiation conditions and induced pluripotent cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25340033
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Hiroshima University
• Principal Investigator: KAWAI HIDEHIKO 広島大学, 原爆放射線医科学研究所, 助教 (30379846)
• Co-Investigator(Kenkyū-buntansha): SHIMAMOTO AKIRA 広島大学, 大学院医歯薬保健学研究院(薬), 准教授 (70432713)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 放射線照射条件 / iPS細胞

Outline of Final Research Achievements

In order to uncover the underlying mechanisms of genotoxic stress-induced biological effects, we have analyzed the cellular and molecular responses to various types of genotoxic stress in various types of cultured cell lines, including human induced pluripotent stem (hiPS) cells and p53-mutated iPS cells. As a result, we have found that iPS cells maintain their genomic stability thorough both p53-depnendent and -independent apoptotic pathways. These results provide important clues to the understanding of the mechanisms of maintaining genomic stability in multi-potent or tissue stem cells, and the improvement of the quality control of those cells.

Free Research Field

放射線生物影響