Elucidation of signal transduction pathway related to a radiation resistance of the nematode

2015 Fiscal Year Final Research Report

• Project/Area Number: 25340037
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Tokai University
• Principal Investigator: ISHII Naoaki 東海大学, 医学部, 教授 (60096196)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 放射線 / 老化 / 活性酸素 / C. elegans / ホルミシス / シグナル伝達経路 / MXL-3 / SKN-1

Outline of Final Research Achievements

We have previously shown that X-ray irradiation extends lifespan and up-regulates the expression of mxl-3 at a dauer larval stage of the nematode Caenorhabditis elegans.
It is well known that reactive oxygen species generated from radiation react with water in vivo contributes to the cellular damages and it is reported that MXL-3 binds to SKN-1 related to oxidative stress. In fact, mxl-3 mRNA levels was up-regulated in wild type worms exposed to paraquat and then the mxl-3 mutant was hypersensitive to paraquat and is short lived under oxygen stress of high concentration.Our result raise the possibility that MXL-3 is involved in response to oxidative stress in collaboration with SKN-1.

Free Research Field

放射線生物学