Basic researches for analysis of mechanism and development of prediction and prevention on arsenic-mediated skin cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 25340052
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Nagoya University
• Principal Investigator: Yajima Ichiro 名古屋大学, 医学系研究科, 講師 (80469022)
• Co-Investigator(Kenkyū-buntansha): 武田 湖州恵 中部大学, 生命健康科学部, 准教授 (80345884)
• Co-Investigator(Renkei-kenkyūsha): KATO Masashi 名古屋大学, 大学院医学系研究科, 教授 (10281073)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ヒ素 / 重金属 / 発癌 / 皮膚癌

Outline of Final Research Achievements

Since two hundred millions people are using arsenic-polluted well water for drinking, a large number of people develop arsenic poisoning including skin cancer and neural diseases. Although it is a vitally important problem in the world, there is no effective method for prediction, prevention, diagnosis and therapy. Our fieldwork analysis on arsenic-polluted area in Bangladesh and experimental analysis in our laboratory found that the amount of Placental Growth Factor (PlGF) protein was increased in urine of people who are drinking arsenic-polluted well water and also elucidated the mechanism of arsenic-mediated skin cancer development via PlGF.

Free Research Field

毒性学