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2015 Fiscal Year Final Research Report

Establishment of neonatal animal model for early detection of environmental pollutant induced-learning disability

Research Project

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Project/Area Number 25340066
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental impact assessment
Research InstitutionNational Institute for Environmental Studies

Principal Investigator

Win-Shwe Tin-Tin  国立研究開発法人国立環境研究所, 環境健康研究センター, 主任研究員 (00391128)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywords神経毒性 / 学習行動 / 新生児モデル / 環境汚物質 / マウス
Outline of Final Research Achievements

We have established a novel olfactory-based spatial learning test and examined the effects of exposure to nano-sized diesel exhaust-origin secondary organic aerosol (SOA) on the learning performance in preweaning mice. Pregnant BALB/c mice were exposed to clean air, diesel exhaust (DE), or DE-origin SOA (DE-SOA) from gestational day 14 to postnatal day (PND) 10 in exposure chambers. On PND 11, the mice were examined by the olfactory-based spatial learning test. The mice exposed to DE or DE-SOA took a longer time to reach the target as compared to the control mice. N-methyl-D-aspartate (NMDA) receptor subunits NR1 and NR2B, and immunological markers such as TNF-α, COX2, and Iba1 mRNAs were significantly increased in the hippocampi of the DE-SOA-exposed preweaning mice as compared to the control mice. Our results indicate that DE-SOA exposure during developmental period may affect the olfactory-based spatial learning behavior in preweaning mice.

Free Research Field

環境学

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Published: 2017-05-10  

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