Inhibitory effects of ellagitannin on allergy as a food supplement

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350112
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Kawasaki University of Medical Welfare
• Principal Investigator: Nagano Takao 川崎医療福祉大学, 医療技術学部, 教授 (20304660)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: エラジタンニン / ザクロ / 大豆イソフラボン / 接触過敏症 / アレルギー性接触皮膚炎 / アレルギー

Outline of Final Research Achievements

Murine contact hypersensitivity (CHS) is one of the most frequently used animal models of human allergic contact dermatitis (ACD). In this study, we investigated the inhibitory effects of diets supplemented with pomegranate polyphenol concentrate (PPC) on CHS. The results indicate that low doses of dietary PPC alleviate CHS symptoms by attenuating inflammation via downregulation of CXCL2 and CCL12, suggesting that dietary supplementation with PPC may provide beneficial effects on ACD at physiologically relevant doses to humans. Furthermore, it is suggested that the synergically inhibitory effects of PPC and soybean isoflavone on CHS.

Free Research Field

食生活学