Development of nutritional therapy that contributes to prevention and treatment of exercise induced hemolysis

2017 Fiscal Year Final Research Report

• Project/Area Number: 25350129
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Kyoto Prefectural University
• Principal Investigator: Kobayashi Yukiko 京都府立大学, 生命環境科学研究科, 助教 (10381930)
• Project Period (FY): 2013-04-01 – 2018-03-31
• Keywords: 運動誘発性溶血 / スポーツ貧血 / 鉄代謝 / 酸化ストレス / 運動負荷ラット / キシロオリゴ糖 / 栄養療法

Outline of Final Research Achievements

We examined the onset mechanism of sports anemia in response to exercise induced hemolysis and iron deficiency and searched for effective nutrients for exercise induced hemolysis. We performed acute and chronic high intensity exercise tolerance tests of rats under various conditions and compared physiological and iron metabolic fluctuations. As a result, it was shown that exercise induced hemolysis model rats can be prepared. Because intake of uronic acid bonded xylooligosaccharide, which has been shown to be useful for prevention and improvement of iron deficiency anemia, has led to suppression of hemolysis inducing factors such as lactic acid production and muscle damage in exercise induced hemolytic model rats, we suggested that uronic acid bonded xylooligosaccharide is one of nutrient components contributing to the prevention of sports anemia.

Free Research Field

栄養科学、臨床栄養学