Does copy number variation of AMY1 gene affect dieatary intake and development in children?

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350141
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Juntendo University
• Principal Investigator: Yoshio Suzuki 順天堂大学, スポーツ健康科学部, 准教授 (30612395)
• Co-Investigator(Renkei-kenkyūsha): KADOYA Haruka 順天堂大学, スポーツ健康科学部, 准教授 (10420879)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: amylase / saliva / AMY1 / development / protease / copy number variation / lifestyle

Outline of Final Research Achievements

Human salivary amylase gene (AMY1) has copy number (CN) variation. The CN is reported to correlate with amount and activity of salivary amylase in adults. Salivary amylase activity is not present at birth and rises to reach maximum levels by puberty. Dietary habit is also reported to affect the activity. This study aimed to clarify how AMY 1 CN and dietary habit affect the development of salivary amylase activity in children. A survey was conducted at Nagano city to collect saliva and questionnaires from 234 nursery and 945 preliminary school children. AMY1 CN was assessed in 204 nursery school children, and DNA was prepared in 943 preliminary school children. Salivary amylase activity before breakfast was associated with AMY1 CN and bedtime in nursery school boys.
In addition to above, the human saliva was suggested to have protease activated at acidic condition. Analysis of questionnaire gave some associations of children and maternal health with lifestyles.

Free Research Field

食生活学