Nutritional research for controlling gonadal development suppression induced by disruption of daily rhythm

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350148
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Kanagawa Institute of Technology
• Principal Investigator: Hanai Miho 神奈川工科大学, 応用バイオ科学部, 教授 (70337781)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 連続暗黒飼育 / 雄性器 / テストステロン / 生殖器官 / 栄養素 / 生活リズム

Outline of Final Research Achievements

Suppression of gonadal development occurs in rats kept in constant darkness. The purpose of this study was to determine the composition of the “improved diet (G-diet)” or “non-improved diet (B-diet)” required for the suppression of gonadal development induced by the constant darkness and to clarify the mechanism of gonadal development control by the diet composition.
The weights of testes from rats given the G-diet, which consists of the 9% casein diet (C-diet) and additional methionine, vitamin E, and pantothenic acid, were higher than those of rats given the C-diet. It is possible that the suppression of testes development in rats fed the C-diet and kept in constant darkness is related to low androgen receptor expression and low dihydrotestosterone synthesis. As such, it is possible that androgen receptor expression and dihydrotestosterone levels improved in rats kept in constant darkness when fed the G-diet.

Free Research Field

栄養学