Cholesterol ingestion and fatty acid composition/insulin resistance during progression of non-alcoholic steatohepatitis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350150
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Kinjo Gakuin University
• Principal Investigator: KITAMORI Kazuya 金城学院大学, 生活環境学部, 准教授 (80387597)
• Co-Investigator(Kenkyū-buntansha): MIYAZAWA Daisuke 金城学院大学, 薬学部, 准教授 (70434553) ; NAKAJIMA Tamie 中部大学, 公私立大学の部局等, 教授 (10020794)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: NASH / コレステロール

Outline of Final Research Achievements

Excessive accumulation of lipid has been considered to be a cause of lifestyle-related diseases but in recent years, changes in the quality of fatty acids is indicated as important. This study used SHRSP5/Dmcr, a non-alcoholic steatohepatitis (NASH) model we developed, in which the disease progresses to fat accumulation/hepatitis/fibrosis upon ingestion of a high-fat and high-cholesterol (HFC) diet, and WKY (control). The rats were fed the HFC diet, a high-fat (HF) diet with no added cholesterol, or a common diet, and measurements of fatty acid composition and inflammation/fibrosis were taken. The cholesterol-added diet caused greater severity of NASH pathology despite having the same lipid content as the HF diet. In addition, the severity was remarkably greater in SHRSP5/Dmcr than in WKY.

Free Research Field

複合領域