Intestinal immunomodulatory and anti-allergic activities of the lipids components in edible basidiomycete fruit body.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350159
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Soai University
• Principal Investigator: Shojo Aiko 相愛大学, 人間発達学部, 准教授 (40517265)
• Co-Investigator(Kenkyū-buntansha): Kitamura Shinichi 大阪府立大学, 生命環境科学研究科, 教授 (60117869) ; Fujiwara Nagatoshi 帝塚山大学, 現代生活学部食物栄養学科, 教授 (80326256) ; Mizuno Seiko 相愛大学, 人間発達学部, 教授 (90190652)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 食用担子菌類 / 腸管免疫 / 腸内細菌 / IgA / パイエル板

Outline of Final Research Achievements

From the data of high-performance liquid chromatography analysis, following results had be demonstrated. The glucosylceramide of edible basidiomycete fruiting bodies had a large difference in that varieties and contained amount. The Differences with the contained amount of neutral lipids and the polarity of complex lipids demonstrated. When the peyer's patch were co-cultured with total lipid of edible basidiomycete fruiting bodies, the cytokines as IL-4, IL-6 and IL-10 were increased. The increased these cytokines in response to total lipids of edible basidiomycete fruiting bodies in the diet compared with a control diet. From these results suggest that the B cell has class-switched to IgA+B cell by the response to IL-4, these class-switched IgA+B cell increased IgA production in response to IL-6.

Free Research Field

食品の三次機能研究としての食用担子菌類をはじめとする食品に含まれる多糖・糖脂質の免疫賦活作用の評価